● Updated April 2026 · Reviewed weekly
Compounded GLP-1 and peptide reviews, with prices that are actually current.
Compound Digest is the independent source for reviews, side-by-side comparisons, and regulatory news on compounded semaglutide, tirzepatide, retatrutide, BPC-157, NAD+, and the peptides people are researching right now. No sponsorships. No hype. Sources on every claim.
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Quick answers
Direct answers to what people actually search.
What is compounded semaglutide?
Compounded semaglutide is a custom-prepared injectable made by a licensed US compounding pharmacy using the same active ingredient found in Ozempic and Wegovy. It is typically prescribed when the branded versions are unavailable or unaffordable, and is dispensed under 503A or 503B pharmacy regulations.
How much does compounded semaglutide cost?
Verified April 2026 pricing ranges from $149 to $449 per month depending on the provider, dose, and whether supplies are included. Telehealth platforms like Henry Meds, Mochi, and Eden cluster in the $199 to $329 range for starting doses. Retail compounding pharmacies with a local prescription can be lower.
Is tirzepatide stronger than semaglutide?
Yes, in head-to-head trial data. The SURMOUNT-5 trial showed tirzepatide delivered about 20.2% average body-weight loss versus 13.7% for semaglutide at comparable durations. Tirzepatide is a dual GIP/GLP-1 agonist, while semaglutide is GLP-1 only. Side effect profiles and cost differ, so stronger does not automatically mean better for every patient.
Is BPC-157 legal in the United States?
BPC-157 is not FDA approved and was removed from the FDA 503A compounding bulks list in 2023, meaning it cannot be legally compounded by a pharmacy for human use. It is widely sold online as a research chemical. Possession for personal use is generally not prosecuted, but it is not an approved therapeutic and is banned by WADA for athletes.
GLP-1 meds at a glance
Average weight loss and monthly pricing across the three most-searched GLP-1 agonists. Verified against manufacturer trial data and provider pricing pages in April 2026.
| Medication | Class | Avg. weight loss | Compounded price / mo | FDA status |
|---|---|---|---|---|
| Semaglutide | GLP-1 | ~13.7% | $149 – $329 | Approved (Ozempic / Wegovy) |
| Tirzepatide | GIP / GLP-1 | ~20.2% | $249 – $449 | Approved (Mounjaro / Zepbound) |
| Retatrutide | GIP / GLP-1 / Glucagon | ~24.2% (Phase 2) | Not commercially available | Investigational |
Start where you’re curious
Four topic hubs, updated continuously. Every review shows its last-verified date.
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GLP-1 Reviews
Compounded semaglutide, tirzepatide, retatrutide. Who prescribes, what it costs, who loses weight.
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Peptide Guides
BPC-157, TB-500, NAD+, CJC-1295, Ipamorelin. Dosing, stacks, sourcing, legality, what research says.
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Provider Comparisons
Hims, Henry, Mochi, Eden, Ro. Price, pharmacy, doctor access, and the fine print.
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Regulatory Tracker
FDA notices, 503A bulks list changes, state board actions. The news that actually moves this market.
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Frequently asked about GLP-1s and peptides
Is compounded semaglutide the same as Ozempic?
No. Ozempic is Novo Nordisk’s branded semaglutide. Compounded semaglutide is made by a licensed compounding pharmacy as a sterile injectable using the same active ingredient. Same molecule, different manufacturer, different price, different regulatory pathway. Our compounded vs branded guide breaks down the specifics.
Which compounded GLP-1 provider is cheapest in 2026?
As of April 2026, Mochi and Henry Meds lead on price for compounded semaglutide starting doses, typically in the $149 to $229 per month range. Tirzepatide is higher across all providers. We maintain a live price tracker in the provider comparisons hub, updated every week.
What are the side effects of compounded semaglutide?
The most common side effects are nausea, vomiting, diarrhea, constipation, and fatigue, especially during dose titration. Less common but serious risks include pancreatitis, gallbladder disease, and thyroid C-cell tumors (boxed warning). Side effects from compounded formulations mirror branded semaglutide when the active ingredient is pharmaceutical grade.
Is BPC-157 still legal to buy in 2026?
BPC-157 sits in a legal gray zone. It is not FDA approved, was removed from the FDA 503A compounding bulks list, and is commonly sold as a research chemical not for human use. Possession for personal research is generally not prosecuted, but it is not an approved therapeutic and WADA bans it for competing athletes.
What peptides are actually worth stacking for recovery?
The most researched recovery peptides are BPC-157 and TB-500 (thymosin beta-4), often stacked together for soft tissue and tendon recovery. Human evidence is limited; most data comes from animal studies. CJC-1295 and Ipamorelin are commonly stacked for GH secretion. Always consult a clinician and understand that these are not FDA approved for human therapeutic use.
Does NAD+ injection actually do anything?
Evidence for NAD+ is early. Small studies and anecdotal reports suggest improvements in energy, cognitive clarity, and metabolic markers, but the category lacks large randomized trials. NAD+ injection and IV therapy are available from compounding pharmacies and med spas; response varies widely. Our NAD+ guide covers what the research actually supports.
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Evergreen posts are refreshed weekly. Last-verified dates on every review.
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